January 2017

Foot and ankle issues may boost risk of clinical and radiographic knee OA

In the moment: Knee OA

By Jordana Bieze Foster

In individuals at risk for knee osteoarthritis (OA), the presence of foot and ankle symptoms is associated with increased odds of developing symptomatic and radiographic knee OA four years later, according to research from the University of Melbourne in Australia.

Investigators analyzed 1020 individuals from the Osteoarthritis Initiative database who had risk factors for knee OA but no symptoms or radiographic evidence of the disease. Those who had foot or ankle symptoms at baseline were 3.28 times more likely than those who did not have foot or ankle issues to develop symptomatic radiographic knee OA four years later. Radiographic knee OA was defined by a Kellgren-Lawrence score of 2 or higher.

The odds of developing symptomatic radiographic knee OA were 3.08 times higher in individuals with contralateral foot/ ankle symptoms at baseline than those without. In those with bilateral foot/ankle symptoms at baseline, the odds of symptomatic radio­graphic knee OA were 4.02 times higher than in those with no foot or ankle issues.

The findings were epublished in December by Osteo­arthritis & Cartilage.


Paterson KL, Kasza J, Hunter DJ, et al. The relationship between foot and ankle symptoms and risk of developing knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2016 Dec 7. [Epub ahead of print]

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