August 2012

OA bracing: Longer use does not impair strength

Photo courtesy of Ossur Americas

Dose-response research refutes the com­mon perception that increasing brace wear time leads to muscle atrophy in patients with knee osteoarthritis. In fact, longer bracing duration appears to im­prove hamstring strength as well as in­creas­ing patients’ physical activity levels. 

By Cheryl L. Hubley-Kozey, PhD, and Gillian Hatfield Murdock, PT, MSc

Osteoarthritis (OA), the most prevalent form of arthritis,1 is characterized by the breakdown of articular cartilage. This break­down results from an imbalance between cartilage synthesis and degradation triggered by biochemical and biomechanical pro­cesses.2 More than 27 million individuals in the US3 and 4.4 million Canadians1 report having OA. Given the aging population, increased obesity rates, and sedentary lifestyles, it’s estimated that 25% to 30% of the North American population will develop OA within the next 20 to 30 years.1,3

While articular cartilage changes are the hallmark of OA, other joint structures including bone, ligaments, muscles, and nerves are also affected, leading to pain and physical function limitations.4 These functional limitations contribute to the staggering economic burden of OA. In the last decade, direct health care expenditures reached $328 billion5 and more than $10 billion1 in the US and Canada, respectively.

The knee is the joint most often affected by OA. For adults older than 65, knee OA results in more difficulty with typical activities of daily living, such as walking and climbing stairs, than any other medical condition.6 However, what is more alarming is that the group of adults aged 45 to 54 years is growing more rapidly than any other age group with knee OA.7

There is no cure for knee OA and total knee arthroplasty is the end-stage treatment for advanced disease. Joint arthroplasty is not a practical solution for those in younger age categories as implants have a lifespan of 15 to 20 years, and patient satisfaction and out­comes dramatically decrease following revision surgery.8 Research­ers once thought OA was primarily a degenerative pro­cess, but the thinking over the past decade has changed to support the idea that OA is a metabolically active process that can be delayed with an optimal environment.4 Hence, there is an urgent need to develop interventions that delay OA progression.9

Pharmaceutical agents have been the mainstay of OA manage­ment, particularly the management of OA-related pain. Although pain relief has a positive impact on quality of life, long-term pain medication usage has been associated with an increased risk of tibial cartilage defects10 and knee OA progression.11 It is thought that the increased risks could be due to deleterious effects on the articular cartilage or to excessive loading on an analgesic-affected joint.11 The latter hypothesis is supported by reports of increased joint loading following pain relief in those with moderate knee OA.12,13 For these reasons, international knee OA management guidelines recommend that the initial OA treatment should include nonpharmacological interventions and, if pharma­cological pain-relieving agents are used, they should not be used long-term.14,15

Disease-modifying pharmacological agents are also being developed to disrupt the imbalanced biochemical processes asso­ciated with OA16 along with biological products to replace damaged tissue,17 but there is also a focus on altering the biomechanical environment. Based on evidence from animal models,18-20 theo­retical models,21,22 and empirical data,23 loading forces are considered catalysts for initiating the degener­ative process and for disease progression. The theory is that if the biomechanical loading forces that cause the initial tissue damage are not removed, the new biological replacement tissue will break down as well.4

Since knee OA is a progressive disease, those with mild to moderate disease have the greatest potential to benefit from conservative interventions aimed at slowing disease progression by altering the biomechanical environment. Researchers have exam­ined knee joint biomechanics and muscle activation patterns using gait as the model21,22,24-26 to understand the mechanical loading environment in knee OA. But only recently have researchers begun to study these characteristics in patients with less advanced OA and across the severity spectrum.25-30 This information is necessary for developing and evaluating treatments as well as for determining which changes are predictive of faster progression.

The medial tibiofemoral compartment is often the main knee compartment afflicted with OA.31,32 Only one study to date has found the peak knee adduction moment during walking, a surrogate measure of medial compartment loading, was predictive of knee OA progression,23 but numerous cross-sectional studies have related alterations in knee adduction moment characteristics to knee OA severity.25,30,33,34 This has led to development of inter­ventions such as heel wedges and knee braces that attempt to reduce knee adduction moment characteristics.35

These recent cross-sectional studies are also showing that other biomechanical and muscle activation characteristics reflecting the dynamic loading environment of the knee joint are associated with disease severity, including frontal, sagittal, and transverse plane mechanics,25,26,30,33 and muscle coactivation and imbalances.29,36-38 This research implies the effectiveness of conservative interventions should perhaps not be based solely on their effect on a single mechanical variable: the peak knee adduction moment.

Valgus unloader braces

Despite OA management guidelines recommending interventions that alter the knee mechanical environment,14,15,39-41 new research has found that physicians treat patients with OA by prescribing medications for pain and inflammation or referring for surgical interventions rather than prescribing treatments that address the underlying mechanisms of disease progression.42 Unloader bracing is one conservative management intervention that has potential to alter the mechanical loading environment of the knee joint, yet is underutilized.41,43 Beaudreuil et al41 provide an excellent review of the evidence supporting unloader braces, identifying two areas in need of research. One relates to improving understanding of the biomechanical mechanisms for brace effects, given that inconsistent findings have been presented in the literature; the other determining optimal duration (dose) for brace wear.

Briefly, what we know about biomechanical mechanisms are related primarily to the valgus unloader brace, as it is the type of brace most commonly prescribed for medial compartment knee OA. These braces are designed to apply a three-point force system around the knee joint that results in a net valgus (abduction) knee moment, altering frontal plane alignment and theoretically unloading the medial compartment.44-46 While one study showed minimal effects of a valgus unloader brace on the knee adduction moment,51 the majority of 3D gait analysis studies have shown that valgus unloader braces do reduce the knee adduction moment during stance.44,45,47-50 However, these changes are immediate, and studies of the long-term effects of brace wear are not conclusive.52-54

Biomechanical studies are varied with respect to population and brace type, but improvements in pain47,51,53-60 and func­tion51,52,56,58,59,61 associated with brace wear have consistently been reported in the literature. Unfortunately, little attention has been given to studying mechanical alterations in other planes or muscle characteristics that can impact joint loading. This is important, as it may provide additional information about the mechanism by which the brace works. Different theories are emerging, in particular, those focusing on the role of the neuro­muscular system.

In a small sample of individuals with medial compartment knee OA, Ramsey et al found that muscle co-contraction was significantly reduced in early stance phase with the use of neutral alignment and valgus unloader braces (4° of valgus alignment) during walking.46 Based on these results, the researchers hypothesized that the positive effects of braces could be due to increased stabilization, reducing the need for muscle co-contraction. Improved proprio­ception has also been reported with the use of valgus unloader braces, supporting the theory that bracing has a neuromuscular effect.62

In addition, Matsuno et al54 reported increased quadriceps strength with prolonged brace wear that was accompanied by a decrease in tibiofemoral angle and a concomitant increase in medial joint space. They hypothesized this mechanical change was due to improved knee stability, supporting the mechanism proposed by Ramsey et al.46 Ramsey and Russell63 also evaluated the evidence supporting the use of valgus unloader braces, and while they presented a more positive case for frontal plane alterations than Beaudreuil et al,41 they indicated that more work is needed to understand the effectiveness of braces on the neuromuscular system.

Part of the reason valgus unloader braces are underprescribed in the conservative management of knee OA may relate to ambi­guity in prescription instructions. Brace prescription in the research literature has been highly variable, with study participants told to “wear the brace as often as possible,”50,54,59 “wear on a regular basis,”64 “wear for as many hours and for as many days of the week as they wished,”52 “wear during ambulation,”55 “wear for bother­some activities,”56 “wear brace as instructed by physiother­apist or orthopaedic technician,”46,61 and “wear for prolonged standing and sport.”53 In addition to the varied instruction to patients, few studies report the actual duration of brace wear, making it difficult to ascertain the optimal prescription for benefit, and whether there is an amount of brace wear that may be ineffective or even detrimental.

Dose response

One area of concern for clinicians is the belief that long-duration brace use will result in decreased muscle strength. This thought is primarily driven from the literature on functional knee bracing for anterior cruciate ligament injury. Functional knee braces have been associated with thigh muscle atrophy,65 decreased hamstring performance,66 decreased quadriceps torque,67 and premature muscle fatigue.68 Researchers have hypothesized that muscle impairment is a result of the brace straps causing external compres­sion on the muscles, decreasing blood flow and resulting in poor tissue oxygenation.68  Decreases in knee joint muscle strength69 and increased fatigue70 would be detrimental in patients with knee OA, as both have been found to negatively impact knee joint mechanics, in particular the knee adduction moment, during walking.

So the question is whether the length of time the brace is worn per day would have an impact on outcomes, and on muscle strength in particular.

Our recent study71 is one of the first to examine dose response for valgus unloader bracing in which the effects of braces were examined over a wide range of wear durations. The rationale for looking at dose response is that a traditional randomized controlled study (for nonpharmacological studies in which duration of the intervention is prescribed) may be too restrictive for patients, many of whom have comorbidities, who reside in the community where external variables may affect compliance.72 This appears to be the case for brace studies, as poor compliance rates have been noted in the literature.52,61,73,74

To look at the effect of bracing, a more realistic study design may be to have patients record how long they wear the brace and base dose response on the variability of wear times. We used this approach to examine dose response for muscle strength.71

We asked 24 patients with medial compartment knee OA with Kellgren-Lawrence severity scores ranging from 1 to 4 (out of 5) to wear customized valgus unloader braces “as needed” and record daily hours of brace wear and physical activity (step count measured by pedometer) for six months.71 These patients were not on a wait list for total knee arthroplasty and met functional criteria29 (self-reported ability to walk a city block, jog five meters, and climb a flight of 10 stairs in a reciprocal manner).

Average brace wear duration was approximately five hours per day, but there was a wide range (0-14 hours/day). We measured pain, function (subjective and objective), and lower extremity strength at baseline and follow up and determined relationships between changes in these variables and duration of brace wear.

Although not statistically significant, increases of 5% to 13% for four quadriceps and hamstring strength measures were found at six months. Positive relationships were found between duration of brace wear and change in both physical activity and hamstrings muscle strength: the longer the brace was worn, the greater the activity and strength increases. However, the positive relationship between brace-wear dose response and the hamstring strength increase was weak.71

What may be more important is that longer brace wear duration was not associated with decreased strength over the six-month follow-up period.

The lack of decreased muscle strength with high brace use is consistent with the findings of Matsuno et al,54 the only other study looking at the effect of valgus knee bracing on quadriceps muscle strength. This study, however, was in a more advanced, weaker, and older OA group who wore the brace for long daily durations (al­though actual times were not reported).

Interestingly, our work showed that subjective pain and function improved between baseline and follow up, consistent with the literature,47,51-61 yet there was no dose response for these variables.71 Regardless of how little the brace was worn, perceived pain and function improved, although objective measures of function (walking velocity) did not.

This finding, combined with the positive relationship between brace wear dose and change in physical activity, suggests that there may be different patient-specific strategies for wearing the brace. Our study included younger participants with less severe disease than the study Matsuno et al, but the brace wear use was varied, with the longer wear times reported for the older patients with more severe disease and less active participants. The more active people tended to wear the brace less, perhaps only wearing it for specific activities. Conversely, the less active people tended to wear the brace more and the result was an increase in their physical activity levels.

Only two biomechanics studies have asked participants to record their hours of daily brace wear; these reported mean brace wear durations and standard deviations of 6.9 (4.6)52 and 9 (5)50 hours per day. Hewett et al52 did not find a change in knee adduction moment after six months of brace wear, whereas Draganich et al50 found reduced knee adduction moments after only five weeks. This difference is not likely due to the two-hour difference in brace wear per day, but may be related to the severity of OA in the Hewett study.  Hewett’s participants were young, with a mean age of 41 years, and the majority had had a previous injury. Draganich’s study participants were closer in age (50 years) to our study participants, and we included those with primary OA (i.e., not those with OA secondary to an injury).

The findings of these two biomechanical studies, in addition to our study on dose response, suggest that higher brace wear times do not negatively impact muscle strength or knee adduction moment parameters.

Future research

Our single dose response study71 had a relatively brief follow-up period, hence longer term studies are needed. Furthermore, additional work is needed to determine whether dose affects knee joint kinematics and kinetics and muscle activation patterns that have been found to be altered immediately following brace applica­tion.44-48,51

We are presently expanding our dose-response analysis to include 3D kinematic and kinetic dynamic waveform data and muscle activation patterns to better understand joint loading throughout the gait cycle. Preliminary findings suggest that changes in specific variables are related to brace wear time. This information will improve our understanding of whether there is an optimal wear time for positive mechanical results.

In addition to looking at dose response of the valgus unloader brace, an important piece of the puzzle is determining which pa­tients are the best candidates for bracing. The variability in response to braces in our study and others implies that there are responders and nonresponders; identifying these individuals and their dose response patterns would be valuable.

Preliminary work from our laboratory has shown that not all individuals respond with a reduced knee adduction moment follow­ing brace application. Some individuals experience decreased knee adduction moments during walking with a brace, while others have increased knee adduction moments.75 These differential effects were found in the first two weeks of wearing the valgus unloader brace. Superficially, this might indicate that the brace may actually worsen the mechanical loading environment at the knee in some subgroups. However, the knee adduction moment magnitude does not provide the entire story with respect to the joint loading environment.

A comprehensive 3D motion and force analysis, along with the muscle activation patterns, will provide more complete information. Follow-up studies are needed to determine whether the different responses persist over time and, if so, whether we can identify subgroups of responders and nonresponders with respect to symptoms, joint mechanical characteristics, and structural pro­gression.

Clinical implications

Despite numerous studies showing that valgus unloader braces improve symptoms and evidence that they alter the mechanical environment of the knee, this conservative management option remains underutilized in knee OA management, perhaps because of ambiguity in prescription parameters or concerns about muscle impairment with prolonged use.

While more dose-response studies are needed to determine the optimal duration of brace wear and the effects of bracing on the mechanical loading environment of the knee joint, the available literature indicates that, in terms of pain, function, activity, and muscle strength, there is potential benefit and no harm in wearing the brace as needed, even for prolonged periods of time.

Cheryl Hubley-Kozey, PhD, is a professor in the schools of Physio­therapy and Biomedical Engineering at Dalhousie University in Halifax, Canada, whose research focus is on improving function of those with musculoskeletal conditions. Gillian Hatfield Murdock, PT, MSc, is a physiotherapist and doctoral candidate in the School of Biomedical Engineering at Dalhousie who is interested in the rela­tion­ship between physical activity and knee OA progression.

Acknowledgements: Canadian Institutes of Health and Nova Scotia Health Research Foundation.  


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One Response to OA bracing: Longer use does not impair strength

  1. Shelley edson says:

    I disagree with the assumptions that long term use of an unloader brace will not impact muscle strength. I am now undergoing PT to try to regain some of the loss muscle strength – as I can no longer climb stairs without using the rails to pull myself up. I have lost a lot in my quads in that leg.
    That is the negative. Here is the positive. I wear the brace when I am going to be physically active -eg exercise classes, swimming (5x a week), going shopping etc. Average use is not going to exceed 3 or 4 hours a day – some days I don’t wear it at all.
    I also have severe osteoarthritis – right lateral and medial compartment. My GP suggested an Ossur brace 2006 – My otho said okay but I still needed surgery someday. I am now 74. My brace is now 12 and I love it. Mostly pain free – 5 tylenol a week max. No plans for surgery ever. But I really want to regain a lot of the muscle strength – quads – that I have lost throughout the years.

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