May 2019

EXCERPT: Do alterations in muscle strength, flexibility, range of motion, and alignment predict lower extremity injury in runners: a systematic review

Strategies for preventing running-related injury are lacking. These authors examine the evidence supporting use of musculoskeletal clinical assessments to predict runners at risk.

By Shefali M. Christopher, Jeremy McCullough, Suzanne J. Snodgrass, and Chad Cook

Injury in runners is common, affecting 19.4 to 94.4% of runners annually. A high incidence of lower extremity running injuries such as Achilles tendinopathy, anterior and/or lateral knee pain, hamstring injury, stress fractures, or medial tibial stress syndrome, is reported commonly in the scientific literature. Despite widespread research on running injuries and their treatment, there are few long-term strategies or guidelines for preventing injuries in runners. Alterations in objective musculoskeletal clinical assessments that predict whether a runner is at risk of injury might potentially form the basis of long-term prevention strategies.

A method for identifying those at risk for future running-related injuries is necessary in clinical or community wellness settings. Recently, researchers have focused on developing models to predict running-related injury (RRI) by examining the interaction of factors such as training related characteristics (i.e. work load) and acute to chronic workload ratios (i.e. changes in weekly running distance). Several studies have investigated running gait and formally evaluated kinematic and  kinetic factors that may predict or differentiate an injured runner from an uninjured runner. However, kinematic measures used in laboratories are not readily transferable to clinical practice, as they require complex equipment such as force plates and motion analysis systems.

 

In practice, clinicians use objective assessments to determine alterations in muscle strength, muscle flexibility, joint range of motion, and alignment during evaluation of runners. Clinicians use results of these tests to explain RRI to patients as these assessments have been hypothesized to be associated with running injuries. They often rely on the results of single studies reporting individual tests as well as studies that use cross sectional designs. To our knowledge, alterations in objective musculoskeletal clinical assessments have not been formally investigated for their ability to predict injury in runners in a systematic review. Therefore, the objective of this review is to identify alterations in muscle strength, flexibility, joint range of motion, and alignment that may predict lower extremity injury in runners in order to improve future statistical modeling for injury risks in runners. Syntheses of clinical assessments’ utility may assist clinicians who commonly use stand-alone findings from single cross-sectional studies to evaluate risk in athletes.

Methods

This study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement during the search and reporting phase of this systematic review. The systematic review was also registered with PROSPERO International prospective register of systematic reviews (CRD42016020087).

For details on search strategy, inclusion/exclusion criteria, study selection, data extraction, and quality of studies, please see original at URL on the bottom of this page.

Results

Search results

Initially, before 189 duplicates were removed, the search yielded 916 results (PubMed 317, Embase 379, SPORTDiscus 33, CINAHL 179, and 8 via hand search). After the first screening, 50 full-text articles were retrieved. Following a consensus meeting, seven articles were included in this review.

Quality of studies

The results of the assessment of quality of each study using the critical appraisal (CAT) tool are reported in Table 1. [Editor’s Note: Citations appear in Table 2.]

Among the seven studies included in this review, per the CAT, two were of good methodological quality (> 75%) and five were of moderate quality (50– 75%). The majority of methodological shortcomings were observed in the following items: sample bias (7/7 studies), reporting validity of measures (5/7 studies), justification of sample size (5/7 studies), and reporting reliability of measures (5/7 studies).

The included studies in this review were all observational design, and therefore per the GRADE approach were considered of low quality of evidence overall. When evaluating each domain, the clinical assessment alterations categories were downgraded either for imprecision, indirectness, inconsistency or all three, resulting in very low quality evidence for each clinical assessment alteration investigated in this review. Publication bias refers to the probability of selective publishing and due to the limited amount of studies for each the clinical assessment alterations (up to three) this item was not used to downgrade evidence in this review.

Objective musculoskeletal clinical assessments

Hip strength

Evidence for hip strength was of very low quality (hip abduction strength downgraded due to indirectness, inconsistency, and imprecision whereas the rest were downgraded due to indirectness and imprecision). Of the two studies investigating hip abduction strength, one study reported that stronger hip abduction strength was significantly associated with injured runners (OR = 5.35, 95% CI = 1.46, 19.53) whereas the other study found no significant association. Finnoff et al., also reported a significant protective association with increased hip external rotation to internal rotation strength ratio RRI (OR = 0.01, 95% CI = < 0.01, 0.44). There were no significant associations between hip adduction, abduction to adduction ratio, external rotation, internal rotation, flexion, extension, flexion-to-extension strength ratio and RRI.

Hip joint range of motion

Evidence for hip joint range of motion was of very low quality (downgraded due to indirectness and inconsistency). Two studies investigated hip internal and external range of motion, of which one study found that increased hip internal rotation was protective against RRI in females that developed medial tibial stress syndrome (aOR = 0.91, 95% CI = 0.85, 0.99).

Hip alignment

Evidence for hip alignment was of very low quality (Q angle downgraded for indirectness and inconsistency, and leg length downgraded for imprecision). Two studies investigated Q angle and one study investigated leg length. The studies were unable to find significant relationships between hip alignment tests investigated and RRI.

Hip flexibility

Evidence for hip flexibility was of very low quality (downgraded for indirectness and imprecision). One study investigated straight leg raise and did not find significant association between straight leg raise test and RRI.

Knee strength

Evidence for knee strength was of very low quality (downgraded for indirectness and imprecision). One study investigated knee strength using a hand-held dynamometer (HHD) and did not find a significant association between quadriceps strength or hamstring strength and RRI.

Ankle alignment

Evidence for ankle alignment was of very low quality (navicular  drop downgraded for indirectness and inconsistency, and foot posture index downgraded for indirectness and imprecision). Three studies investigated navicular drop and the development of running injuries. One study found a significant protective relationship between decreased navicular drop amount in females and injury (HR = 0.92); two studies did not find a significant relationship between navicular drop and injured runners. One study investigated the Foot Posture Index and did not find a significant relationship between foot posture and injured runners.

Ankle joint range of motion

Evidence for ankle range of motion was of very low quality (downgraded for indirectness). One study investigated ankle dorsiflexion range of motion and did not report a significant association between ankle dorsiflexion (in knee straight and bent) and RRI.

Discussion

Findings within the studies

The goal of this study was to summarize the results of stand-alone studies that have investigated clinical assessment and risk of injury. Synthesizing the work should improve an understanding of which factors may be transferable to a clinical environment. Stand-alone findings such as increased hip external to internal rotation strength ratio and decreased navicular drop were protective of injury, but only in a few studies. We also found that increased hip abduction strength was predictive of injury and decreased hip internal rotation was protective of injury in runners, largely contradicting clinical thought and results from non-longitudinal studies of association. In no cases did we find compelling evidence from multiple studies of common predictors of injury risk in running. Also, all clinical assessment alteration categories had very low quality of evidence; therefore, clinicians should be very cautious interpreting the results below.

As stated, increased hip external to internal strength ratio was seen to be protective for injury in runners that developed patella femoral pain syndrome. This finding was reported in one study by Finnoff et al. Although the authors did not operationally define this ratio, it is assumed that an increase in hip external rotator strength when compared to internal rotator strength would be protective for runners. The hip external rotators muscles control femoral internal rotation and a lack of control may be linked with running injury. It is important to note there were several confounders in this study. The study did not report running distance per week (mileage) nor did it report any injury history, both of which have been associated as risk factors for injury. Because these athletes were high school runners, these factors could have significantly influenced results.

Decreased navicular drop was seen to be protective of injury in this review. This finding was reported in one study; however, it was not significant among the two other studies that did investigate this measure. Excessive pronation of the foot causes tibial rotation and has been seen to be related to medial stress syndrome in runners. This finding was investigated in novice runners participating in a 13-week training program for a 4-mile running event and therefore cannot be applied to all running populations in general.

Increased hip abduction strength was found to be predictive of injury in one cohort study. The finding that runners with stronger hip abductors were more associated with RRI may have been due to a number of confounders. The participants included in the study were high school athletes, possibly novice runners. As mentioned before, weekly training mileage and injury history were not reported. Finnoff et al. theorized that the injured subjects in the group had higher body mass index (BMI), which could have led to higher hip abduction moments. To compensate for these larger moments, the runners may have developed increased hip abductor (eccentric) strength over time. This finding shows that some injured runners may have increased strength, specifically if they are younger or novice runners with a higher BMI. Caution should be used when interpreting this result with all running populations.

Decreased hip internal rotation was found to be protective in one cohort study. Excessive hip internal rotation has been associated with injury during jump landing tasks and lack of control of the lower extremity in the frontal and transverse planes has also been hypothesized as a cause for injury in runners. Decreased mobility could therefore be beneficial and protective for runners, as it would require less neuromuscular control. This finding shows that stiffness in runners may not be an impairment as previously thought, specifically if they are young and may not have developed the neuromuscular control needed to stabilize the limb. Caution should be used while interpreting the findings of this study as participants were high school runners. Shin pain was the only injury reported. Mileage of the runners was not reported; however, frequency of training was. Experience was noted as national, state, or entry level, however no history of running injury or amount of running miles was reported.

Findings between the studies

The GRADE level of evidence quality was very low for all objective assessment alteration categories included in this review. Studies were downgraded for either indirectness, inconsistency, imprecision or all three. There were no common predictors across a number of studies in this review. There may be several reasons for the lack of commonality or the occasional findings that are contradictory to clinical thought, such as differences in subject demographics, different measurement methods, measurement variability within clinical assessments, inconsistent definitions of injury and runner, different statistical models, and study bias. These issues have been further addressed below.

There were a wide range of different assessments used to compare clinical assessment alterations and future injury within the seven prospective studies, and studies used different methods when measuring the same construct. For example, ankle alignment was measured with navicular drop or Foot Posture Index. This lack of homogeneity between studies resulted in difficulties comparing clinical assessments between studies, even when studies focused on a similar construct (e.g., alignment).

A variety of methods was used to define and report the clinical assessments, even when the same testing device was used. For instance, weakness in hip HHD assessment was often reported by asymmetry between left and right sides. However, another study divided strength into three tertiles (weakest, middle and strong) across participants and used the strongest strength values as the comparator. One study multiplied the HHD reading by the moment arm and then normalized it to the participant’s body mass. The other studies normalized HHD values to body mass and height. This variability in the reporting of muscle strength assessments made it difficult to compare studies, perform meta-analyses, or identify common patterns of muscle strength in included prospective studies.

Population and injury definitions were also heterogeneous among studies. Running populations in studies varied from novice to recreational, with more males than females in the Q angle studies. Running related injury has been defined many ways in the literature, as evidenced by the wide variability of injury incidence rates reported in various studies. When defining an injury, studies used: 1) evaluation by a medical physician, athletic trainer or physical therapist, 2) presence of pain with duration of symptoms > 24 h, 3) decrease in running mileage, 4) missed workouts or, 5) a combination of the variables listed, all of which were included in our study. Consistent reporting about injury severity, the course of treatment, previous injury, or whether the runner had sought assistance from a health care provider was lacking. Difference in levels of injury severity would likely alter associational modeling and influence the statistical significance of the findings.

Lastly, statistical modeling was different among studies. Three studies used a multivariable model, whereas four studies used a bivariable model. Among the three studies that used a multivariable model, measures of independent variables such as age, other clinical tests and BMI were also included in the regression analysis model. This could have influenced the relationship between singular clinical test (such as navicular drop) and RRI.

Previous reviews investigating the risk of RRI have also reported similar criticisms. Winter et al. investigated fatigue and RRI and were unable to find conclusive patterns of associations due to a lack of homogeneity of the runners, small sample sizes, and the distances that were run to determine fatigue. A systematic review studying vertical ground reaction force and injury was also unable to make recommendations due to a lack of prospective studies investigating this variable and its association with injury. When reviewing biomechanical risk factors, Aderem and colleagues concluded that shod female runners with iliotibial band syndrome may have associated increased peak knee internal rotation and peak hip adduction during stance (based on one prospective cohort study), but because of limitations in effect size and the number of studies and methods, the authors did not make any additional recommendations. In the one review that investigated alterations to the musculoskeletal system, similar to the current study, i.e., plantar pressures, the authors concluded there was inconsistency among studies and suggested improved methodology for future research.

Limitations

There are several limitations to this review. Studies with post-operative populations were excluded from the study, so it is possible the runners included in the selected studies had less severe injuries, which potentially influenced the clinical assessment alterations between baseline and future injury. This was performed to better generalize the results to the population of runners commonly seen in outpatient community-based clinics, who often present without having seen a surgeon.

Conclusion

Table 2. 7 Included Studies

  • Buist I et al. Am J Sports Med. 2010;38(2):273–80.
  • Finnoff JT et al. PM and R. 2011;3(9):792–801.
  • Hespanhol Junior LC et al. Eur J Sport Sci. 2016;16(8):1137–44.
  • Luedke LE et al. Int J Sports Phys Ther. 2015;10(6):868–76.
  • Plisky MS et al. J Orthop Sports Phys Ther. 2007;37(2):40–7.
  • Ramskov D et al. Int J Sports Phys Ther. 2013;8(4):407–15.
  • Yagi S et al. Knee Surg Sports Traumatol Arthrosc. 2013;21(3):556–63.

This review suggests that objective assessments that measure alterations in muscle strength, flexibility, alignment, and range of motion of the lower extremity had very low quality of evidence. Within the studies there were several confounders such as participant’s experience, unknown injury history, and unknown weekly running mileage, all of which have been seen to be associated with RRI. Among the studies, there were a limited number of studies investigating each assessment, inconsistent results, different measurement methods among studies, measurement variability within clinical assessments, inconsistent definitions of injury and runner, different statistical modeling, and study bias. Future studies should aim to improve the quality of the studies as well as use standardized assessments and minimize confounders when conducting clinical research to predict injury in runners.

Shefali Christopher is a sports physical therapist in the department of physical therapy education at Elon University in Elon, North Carolina; Suzanne Snodgrass is an Associate Professor in the School of Health Sciences at the University of Newcastle in Australia. Jeremy McCullough is a physical therapist with Pivot Physical Therapy in Culpeper, Virginia. Chad Cook, PhD, FAAOMPT, is vice chief of research for the doctor of physical therapy program at Duke University.

Note: This article has been excerpted from “Do alterations in muscle strength, flexibility, range of motion, and alignment predict lower extremity injury in runners: a systematic review,” by the same authors, which appeared in Archives of Physiotherapy; 2019;9:2. References and methodological details have been removed for brevity. Use is per the Creative Commons Distribution 4.0 International License. To read the full article, got to https://doi.org/10.1186/s40945-019-0054-7.

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