This study provides the first insights into fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise. The fast fibers were more responsive to exercise with divergent transcriptome signatures among young exercisers (growth and metabolic), lifelong exercisers (metabolic), and old healthy nonexercisers (stress). Only lifelong exercisers had a biological response in slow fibers (metabolic). These data provide novel insights into fast and slow muscle fiber health at the molecular level with age and exercise.
Source: Raue U, Begue G, Minchev K, et al. Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise. J Appl Physiol (1985). 2024;136(2):244-261. doi: 10.1152/japplphysiol.00442.2023.
