Lower Extremity Review
Patients with anterior cruciate ligament injury are at high risk of post-traumatic osteoarthritis and their response to reconstructive surgery and rehabilitation varies. Proteins identified in the orchestration of the acute inflammatory response may be predictive of patient outcomes. These authors used an unbiased, bottom-up proteomics approach…
As medical use of cannabis becomes more common in the treatment of chronic pain, these researchers wanted to better understand the patient perspective of this therapy. Based on semi-structured interviews with 13 chronic pain patients at a hospital-based clinic in Ontario, Canada, patients reported reduced pain…
Researchers from McGill University and Lady Davis Institute for Medical Research in Montreal, Canada, took on the task of examining the ethical considerations physicians face when patients admit to cannabis-impaired driving. As of October 2018, dried forms of cannabis became legal in Canada for adults age 18 and older, and…
As a widely prescribed anti-diabetic drug, metformin (MTF) has been receiving novel attention for its analgesic potential. In the study of the complex etiology of neuropathic pain (NeP), male and female individuals exhibit quite different responses characterized by higher pain sensitivity and greater NeP incidence in women.
Carotid atherosclerosis is the leading cause of ischemic stroke. Carotid intima–media thickness (cIMT) is a validated surrogate marker of atherosclerosis that is independently associated with the risk for cardiovascular disease. It’s presence in the general population has been well documented, with one study showing that…
A unique collaboration between imaging science, vascular medicine, and rehabilitation at Vanderbilt University Medical Center (VUMC) is transforming the diagnosis and treatment of lipedema, a debilitating, abnormal deposition of fatty tissue that afflicts an estimated 17 million women in the United States.
Following on the 2018 ASPREE trial findings that the daily use of aspirin did not improve disability-free survival among aging adults, a new substudy now reports that aspirin (100mg daily) was associated with a higher risk of serious falls (incidence ratio: 1.17; P = 0.01). The researchers recruited…
The blood pressure medication telmisartan did not improve walking performance in patients with peripheral arterial disease (PAD) in the lower extremity, according to new research. These results challenge previous studies that found telmisartan improved running strength in mice and…
It is well known that muscle mass is lost following anterior cruciate ligament reconstruction (ACLR) surgery. These researchers sought to compare muscle strength gain in the quadriceps and hamstring muscles in patients following ACLR surgery using exercises with and without blood flow restriction.
Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy (SMA) may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.
A smart bandage used wireless power to protect and monitor wounds, provide feedback on tissue health, and encourage healing using electrical current. Mice treated with the bandage healed faster than those protected with standard wound dressings. The skin has a remarkable capacity to…
Use of total ankle arthroplasty (TAA) has been on the rise and researchers from Emory University in Atlanta, Georgia, put the numbers together:
The 100m race is the highlight of many track and field events; indeed, in the Olympic Games, it defines the fastest man and woman in the world. In this event, the block start performance and subsequent first 2 steps can be of critical importance since they directly influence the runner’s overall time.
Despite major advances in elucidating the pathogenesis of diabetic peripheral neuropathy (DPN), there remains a lack of disease-modifying treatment options in individuals with diabetes. Currently, there is no convincing evidence supporting glucose control or lifestyle management as therapies for…
For 10 years, John O’Sullivan, founder of the Changing the Game Project and Way of the Champions Podcast, has published his books of the year. Here’s what he has to say for 2022…
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