March 2011

Plantar loads influence knee osteoarthritis risk

Research suggests that redirecting ground reaction forces relative to the knee joint’s rotational center, thus decreasing risk factors for medial compartment osteoarthritis, can be achieved by repositioning the foot through a number of different mechanisms.

By Roy H. Lidtke, DPM, CPed

Osteoarthritis (OA) is the most common form of lower extremity arthritis with close to 30 million people in the U.S. suffering from this debilitating disease.1 One third of all adults over age 65 have osteoarthritis, with the medial knee the most affected joint component.2-4

The economic and societal impact of lower extremity arthritis is a staggering $171 billion per year in direct medical care and job related costs of $13.2 billion per year.5-8 Due to the vast burden of this disease on the U.S. healthcare system, the National Institute of Arthritis and Musculoskeletal and Skin Diseases has identified knee OA as a primary area of research.

Much of the research for the past 20 years has been focused on the biochemical and metabolic processes of cartilage damage and repair. Despite these great efforts, treatment of knee OA remains largely palliative, focusing on oral analgesics and often ending in destruction of the joint and an artificial knee implant. Researchers have only recently returned to investigating the biomechanical pathology that underlies much of the disease progression.

What those researchers have discovered is beginning to change the way we think about joint loading, the influence of the foot on lower extremity mechanics, and even our notions of footwear.

Knee mechanics and the foot

Figure 1a. Ground reaction force (GRF) vector pointing to body center of mass. The force is at a distance from the rotational center of the knee joint, producing an external adduction moment of force. Figure 1b. A valgus wedge under the foot can produce a decreased knee adduction moment by altering the GRF vector, reducing the moment arm.

There are essentially only two sources of aberrant loads on the knee. One is the external ground reaction force (GRF) from gravity acting on the body’s mass, and the other is the internal muscles. During walking, the external ground reaction force vector applied to the lower extremity is counteracted by the internal muscle moments around each joint segment. Since these forces are applied at a distance from the rotational center of the joints, by definition they are considered moments of force. Individuals with a varus alignment of the knee joint have a greater incidence of arthritis related pain and have a larger external adduction moment applied to the knee than those with a more rectus knee.9-12 (Figure 1)

Dynamically, there are two periods where the external knee adduction moment peaks. One is during the loading phase of the gait cycle, the other during the propulsive phase.13 Of all the biomechanical factors that influence gait, the external knee adduction moment has been shown to be most closely associated with the pain14,15 and progression16 of medial knee OA.14-19

The ground reaction force vector originates at the foot-ground interface during the contact phase of gait. So if one wanted to manipulate the position of the ground reaction force vector, the foot-ground interface or plantar aspect of the foot would be a great place to start. The magnitude of the ground reaction force vector is largely dependent on gravity and body mass, both of which are notoriously difficult to influence. However, the direction or position of the ground reaction force vector with respect to the joint rotational center can be manipulated.

One method used by clinicians for many years is the introduction of a valgus wedge under the foot.20 The theory is that the valgus wedge slightly alters the orientation of the ground reaction vector, thereby placing it closer to the rotational center of the knee joint axis.(Figure 2)  Several studies have confirmed a decrease in the peak knee adduction moment associated with either valgus wedges or valgus posting in a foot orthosis.21-23 Studies by Davis et al showed there is a dose dependent response to the wedge in that the minimal amount of wedge valgus angle that provided the maximum reduction in pain was patient-specific. This suggests that determining the optimal angle of the valgus wedge post for each individual patient’s foot orthosis may be the appropriate approach to reducing knee pain and loads across the medial knee in OA.24-26 It is important to keep in mind there have been several studies that show valgus posting or wedges have little beneficial effect on the progression of knee OA.27-29 Clearly continued research is needed to better understand the role the foot in the mechanics of medial knee OA.

Over the past few decades, the work of this author and others at Rush University Medical Center in Chicago has evaluated the effects of various interventions on the biochemistry, anatomy and biomechanics of medial knee OA. Through controlled trials of hundreds of individuals, we have seen significant long-term beneficial effects of manipulating the foot ground interface in some patients and observed others in whom the modifications seem to provide no significant beneficial effects. For those that did complete a multi-year intervention, there was a statistically significant reduction in the loads at the medial knee and reduction in pain.30 Focus soon turned to the question of what allowed the valgus wedge to work amazingly well in some subjects with medial knee OA while others seem to get little benefit.

The answer may lie in an individual’s biomechanics. While conducting this study, this author observed that some patients had considerable frontal plane mobility in the rearfoot that allowed the valgus post to more efficiently alter the leg and knee orientation, while others seem to have a more dominant transverse plane translation between rearfoot motion and leg position. The post hoc analysis of the moment data revealed significantly higher knee adduction moments at  baseline in the high mobility frontal plane dominant group than in the transverse plane dominant group. After three months of both groups wearing the valgus wedge orthosis, the transverse plane dominant group had little to no change in knee moment, while the  high mobility frontal plane dominant group had a significant reduction in peak knee adduction moment.31 Although there was not a significant difference between these groups in terms of pain reduction during the same period, there was a trend for less pain in the high mobility sub-group corresponding to the reduction in knee adduction moments. A possible explanation for the lack of significance is the reduced power due to the smaller sample size, given that these are sub-groups of a treatment group and each represents only half of the enrolled subjects. Recently others have reported similar findings that foot mobility directly affects the magnitude of knee unloading provided by orthotic wedges.32,33

Given these findings and findings from previous work that show a varus posted device increases the peak knee adduction moment, there may be translational value to this knowledge.34 If one can clinically observe greater frontal plane motion of the rearfoot and leg in a subject with medial knee OA, there may be a greater likelihood of reducing the medial knee loads by using a valgus foot-ground intervention. However if there is more transverse plane motion observed in the leg with foot pronation-supination, then other treatment options may be better.

Researchers have focused on not only the peak adduction moment, which represents the largest moment at any one point in time within the stance phase, but also the amount of time spent with large moments applied to the biological tissue. The area under the curve of the knee adduction moment represents the angular momentum acting on the knee and has been shown to be more specific to radiographic severity and patient-reported pain scores in medial knee OA. 35

While researchers continue to work through the multiple possibilities between interventions and patient mechanics trying to scientifically understand the role the foot has the progression of the disease, it remains evident that the foot-ground interface plays a role in medial knee OA.

Plantar foot pressure

Figure 2. To measure the amount of lateral displacement of the COP trace, we determined the widest part of the forefoot and rearfoot, found the midpoint and connected a line to each midpoint. This was labeled as the longitudinal axis from which the distance of COP trace was calculated.

The most direct measurement of the foot ground interface is plantar pressure measurement. This is done either with electronic in-shoe sensors or with an electronic sensor array the barefoot subject walks over. Several studies have shown a relationship between pain, arthritis, and changes in foot pressure.36-40 Most have focused on peak regional pressures or pressure-time integral, but few have looked at the loading pattern during gait.

One way to assess the loading pattern over the entire gait cycle is using a Center of Pressure (COP) trace. This is a calculated measurement based on foot-ground contact area and magnitude of pressure for each pressure sample taken during the gait cycle. For example, if a donut were sitting on the pressure plate, the calculated center of pressure would be at the center of the hole, within the ring where there is no contact.

It would be logical to conclude that if a deviation in foot position altered the ground reaction force vector then there would be a corresponding alteration in the plantar foot pressure pattern.  This is fairly evident in a statically assessed limb with a varus alignment, where there is more pressure under the plantar aspect of the lateral foot.41 Our research concluded that indeed subjects with medial knee OA had a more lateral COP trace during gait than matched controls.42 Moreover, there was a statistically significant correlation between increased pain and and a more lateral deviation in the center of pressure trace. This study showed that those with medial knee OA have a deviated foot ground interface that can be measured with a clinical gait test. It would also seem logical that a treatment, such as an orthosis, footwear, or surgical procedure, that altered the COP trace in a medial direction would benefit those who suffer from medial knee OA. This, however, needs more studies before we can have a definitive answer.

Barefoot loads and shoes

Several years ago, when this author proposed evaluating plantar pressure in knee OA, it was decided that barefoot kinetics and kinematics would be needed to compare to the pressure data.  When data started to demonstrate that barefoot walking produced the greatest reduction in peak knee adduction moment compared to various shoes, orthoses, and braces, the concept seemed counterintuitive to a biomechanist. Most assumed it would be higher since when one walks across a force plate barefoot, greater shock is felt at initial contact compared to a shod condition. But even when the researchers accounted for body weight, height, speed, and step and stride length, the data showed that barefoot walking was associated with the greatest reductions in load.43 This took the work into an area that even today is controversial. That is: What is it about shoes versus barefoot that produces these differences?

One of the first possible explanations came from the fact that most pathology seen in physicians’ offices is related to overpronation of the foot. Shoe companies have responded over the years to make athletic and walking shoes more stable to restrict pronation. This is often accomplished using dual density midsoles, added reinforcement to the midsole, rigid heel counters and extra foxing or layering the upper with extra material to provide medial stability. The end result was a fairly stiff shoe that essentially became a more efficient lever arm to transfer the ground reaction force into the lower extremity. Additionally heels were elevated higher than the forefoot and outsoles were flared out for more stability. This essentially increased the lever arm between the ground reaction force vector and the center of rotation of each of the lower extremity joint segments.  (Figure 3)

Figure 3. Arthritis shoe with orientation of outsole cuts creating flexure zones, which allow the shoe to "break way" at key periods of the gait cycle. This creates a less efficient lever arm to transfer the ground reaction force vectors to the next proximal joint segment.

If shoe construction was to blame for increased loads on the lower extremity, then shoe construction should be able to reduce the loads. This author evaluated the magnitude and location of the external ground reaction force vector at each part of the stance phase of the gait cycle to assess how they could be altered. For example, at initial heel contact, the ground reaction force vector is posterior and lateral to the heel, pointing toward the center of mass of the body.  It is therefore applying an external pronation moment to the ankle and subtalar joints; extension, internal rotation and adduction moments at the knee; and flexion, adduction, and internal rotation moments at the hip. All of these external moments have to be counteracted by the internal muscle moments.

So if one wanted to reduce these moments, one could decrease the lever arm between the posterior-lateral heel and the rotational center of each segment by decreasing the size and thickness of shoe material at the heel. Of course there is only so much that can be reduced external to the body before contact is made at the surface of the heel. Another factor that could be manipulated is the property of the shoe sole material; it can be made soft and compressible, thereby making it an inefficient lever arm. The final way to manipulate the GRF is to have the shoe essentially “break away;” that is, have the contact surface point move as it makes contact with the ground. When this happens, the moment arm becomes less efficient at transferring the load to the next segment and the orientation of the vector can even be slightly altered.

The end result of these experiments was a shoe designed at Rush University with a modified outsole and midsole based on the above described examples. The design was tested in subjects with knee OA, with the results very similar to barefoot walking moments.44 The shoe continues to be evaluated at major universities in the U.S. and U.K. in the treatment of medial knee osteoarthritis.

Researchers have continued to show that stability shoes produced higher moments while flexible shoes and even minimal shoes like flip flops produced less loads across lower extremity joints.45-47 This opened up the flood gates to marketing “barefoot” shoes from manufacturers who were trying to understand the implications of this work.

The final possible rationale for why shoes produce measurable differences is neuromuscular adaptation—the process by which one can more easily feel the ground and sense the pressure/forces being applied to the various tissues that have afferent nerve fibers sending signals along the neurological pathways. Proprioceptive feedback mechanisms can quickly alter a muscle contraction to counteract an external GRF. It may be that shoes somehow alter these neuromuscular feedback mechanisms thereby dampening the response of the internal moments produced by the muscles to the external stimulus of the ground reaction force. Although several authors have published work that demonstrates various changes in the properties of shoe materials can alter balance and gait patterns, it has proven to be very difficult to measure proprioceptive and neuromuscular adaptation with current techniques and technology.48,49

However an observation from the knee OA intervention studies conducted at Rush supports the neuromuscular adaptation theory. In most cases there was an immediate reduction in the external knee adduction moment with the introduction of the mechanical intervention. But the studies also showed a sustained reduction in knee adduction moments or shift in the center of pressure over time even when subjects walked without the intervention. The important point here is that when the mechanical device was removed, the body continued to function as if the intervention was still there. The most logical explanation is neuromuscular adaptation.

It is entirely likely that, as in the case of valgus wedge research, individual biomechanics will dictate which patients with medial knee OA will benefit from a simulated barefoot condition and which will need a more supported stable foot structure. Hopefully research will continue to provide us with more clues. But we all must keep in mind that research only provides us with pieces of truth. It is up to us to assimilate the information.

Roy H. Lidtke DPM, CPed, FACFAOM, is an associate professor of podiatric medicine at Des Moines University in Des Moines, IA; an assistant professor of internal medicine, section of rheumatology, at Rush University Medical Center in Chicago; and director of the Center for Clinical Biomechanics at St. Luke’s Hospital in Cedar Rapids, IA.

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