BMI, body mass index; SSRI, selective serotonin reuptake inhibitor.
Data is derived from a meta-analysis and systematic review of the literature that looked at 42 studies including 28 case-control, 10 cohort, and 4 randomized trials, comprising 31,844 clubfoot cases and 6,604,013 controls. The authors concluded that recognition of modifiable risk factors may help in counseling patients and minimizing clubfoot incidence.
Source: Chen C, Kaushal N, Scher DM, et al. Clubfoot Etiology: A Meta-Analysis and Systematic Review of Observational and Randomized Trials. J Ped Ortho. 2018;38(8):p e462-e469. DOI: 10.1097/BPO.0000000000001191.
