Extended-release corticosteroid injections demonstrated short-term improvements in gait biomechanics, quadricep strength, and physical function for up to 8 weeks. However, non-responders demonstrated gait biomechanics associated with osteoarthritis progression prior to the corticosteroid injection, suggesting that non-responders demonstrate more deleterious gait biomechanics prior to corticosteroid injection. The authors called for future research to determine the mechanisms contributing to the short-term changes in gait biomechanics and physical function such as reduced inflammation.
Source: Lisee C, Bjornsen E, Berkoff D, et al. Changes in biomechanics, strength, physical function, and daily steps after extended-release corticosteroid injections in knee osteoarthritis: a responder analysis. Clin Rheumatol. 2023. doi: 10.1007/s10067-023-06568-x.
