Researchers from Augustana University in South Dakota sought to understand the molecular mechanisms by which estradiol and exercise induce beneficial effects by assessing whole body and cellular changes. They divided a group of female rats into groups—control, exercise (Ex), estradiol replacement, and Ex + estradiol. Only exercise effectively reduced white adipose tissue (WAT) weight gain, food intake, blood glucose levels, and serum insulin levels.
Used with permission from: Fritsch LJ, McCaulley SJ, Johnson CR, Lawson NJ, Gorres-Martens BK. Exercise prevents whole body type 2 diabetes risk factors better than estradiol replacement in rats J App Physiol. 2021;131:5;1520-1531.